Glioma and temozolomide induced alterations in gut microbiome.
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ABSTRACT:
SUBMITTER: Patrizz A
PROVIDER: S-EPMC7713059 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Glioma and temozolomide induced alterations in gut microbiome.
Patrizz Anthony A Dono Antonio A Zorofchian Soheil S Hines Gabriella G Takayasu Takeshi T Husein Nuruddin N Otani Yoshihiro Y Arevalo Octavio O Choi H Alex HA Savarraj Jude J Tandon Nitin N Ganesh Bhanu P BP Kaur Balveen B McCullough Louise D LD Ballester Leomar Y LY Esquenazi Yoshua Y
Scientific reports 20201203 1
The gut microbiome is fundamental in neurogenesis processes. Alterations in microbial constituents promote inflammation and immunosuppression. Recently, in immune-oncology, specific microbial taxa have been described to enhance the effects of therapeutic modalities. However, the effects of microbial dysbiosis on glioma are still unknown. The aim of this study was to explore the effects of glioma development and Temozolomide (TMZ) on fecal microbiome in mice and humans. C57BL/6 mice were implante ...[more]
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