Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression.
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ABSTRACT:
SUBMITTER: Rahmel T
PROVIDER: S-EPMC7713186 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression.
Rahmel Tim T Marko Britta B Nowak Hartmuth H Bergmann Lars L Thon Patrick P Rump Katharina K Kreimendahl Sebastian S Rassow Joachim J Peters Jürgen J Singer Mervyn M Adamzik Michael M Koos Björn B
Scientific reports 20201203 1
Sepsis is characterized by a dysregulated immune response, metabolic derangements and bioenergetic failure. These alterations are closely associated with a profound and persisting mitochondrial dysfunction. This however occurs despite increased expression of the nuclear-encoded transcription factor A (TFAM) that normally supports mitochondrial biogenesis and functional recovery. Since this paradox may relate to an altered intracellular distribution of TFAM in sepsis, we tested the hypothesis tha ...[more]
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