Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi R
PROVIDER: S-EPMC7713301 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Takahashi Ryota R Ijichi Hideaki H Sano Makoto M Miyabayashi Koji K Mohri Dai D Kim Jinsuk J Kimura Gen G Nakatsuka Takuma T Fujiwara Hiroaki H Yamamoto Keisuke K Kudo Yotaro Y Tanaka Yasuo Y Tateishi Keisuke K Nakai Yousuke Y Morishita Yasuyuki Y Soma Katsura K Takeda Norihiko N Moses Harold L HL Isayama Hiroyuki H Koike Kazuhiko K
Scientific reports 20201203 1
Pancreatic cancer is one of the malignant diseases with the worst prognosis. Resistance to chemotherapy is a major difficulty in treating the disease. We analyzed plasma samples from a genetically engineered mouse model of pancreatic cancer and found soluble vascular cell adhesion molecule-1 (sVCAM-1) increases in response to gemcitabine treatment. VCAM-1 was expressed and secreted by murine and human pancreatic cancer cells. Subcutaneous allograft tumors with overexpression or knock-down of VCA ...[more]