Dataset Information

Autoimmune retinopathy: findings and limitations from optical coherence tomography angiography.

ABSTRACT: Background and objective: To report novel findings and limitations from optical coherence tomography angiography (OCTA) in the evaluation of autoimmune retinopathy (AIR).

Study design: We retrospectively reviewed features of five patients diagnosed with AIR and five controls. OCTA scans were obtained and manually segmented to provide accurate measurements of foveal avascular zone (FAZ), vessel density, and retinal thickness at different levels.

Results: The total retina and superficial vessel density throughout the whole scan were similar between AIR and controls (p?=?0.14 and p?=?0.11), whereas deep vessel density was decreased in AIR compared controls (p?=?0.02). Decreased vessel density was most pronounced in the parafoveal and perifoveal areas (p?=?0.01 and p?=?0.01). AIR patients also had reduction of total retinal thickness in the perifoveal zone (p?=?0.03), corresponding to outer retinal thinning (p?=?0.001).

Conclusion: This small series shows that AIR patients have reduced deep vessel density, particularly in the parafoveal and perifoveal regions and a decrease in macular thickness. These findings show correlation with the classic "flying saucer" sign seen on OCT.

SUBMITTER: Raevis J

PROVIDER: S-EPMC7713440 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Autoimmune retinopathy: findings and limitations from optical coherence tomography angiography.

Raevis Joseph J Etheridge Tyler T Cleland Spencer S Mititelu Mihai M

International journal of retina and vitreous 20201203 1

<h4>Background and objective</h4>To report novel findings and limitations from optical coherence tomography angiography (OCTA) in the evaluation of autoimmune retinopathy (AIR).<h4>Study design</h4>We retrospectively reviewed features of five patients diagnosed with AIR and five controls. OCTA scans were obtained and manually segmented to provide accurate measurements of foveal avascular zone (FAZ), vessel density, and retinal thickness at different levels.<h4>Results</h4>The total retina and su ...[more]

PMID: 33292781

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Project description:ImportanceMacular ischemia is a key feature of diabetic retinopathy (DR). Quantification of macular ischemia has potential as a biomarker for DR.ObjectiveTo assess the feasibility of automated quantification of capillary nonperfusion as a potential sign of macular ischemia using optical coherence tomography (OCT) angiography.Design, setting, and participantsAn observational study conducted in a tertiary, subspecialty, academic practice evaluated macular nonperfusion with 6 × 6-mm OCT angiography obtained with commercially available 70-kHz OCT and fluorescein angiography (FA). The study was conducted from January 22 to September 18, 2014. Data analysis was performed from October 1, 2014, to April 7, 2015. Participants included 12 individuals with normal vision serving as controls and 12 patients with various levels of DR.Main outcomes and measuresPreplanned primary measures were parafoveal and perifoveal vessel density, total avascular area, and foveal avascular zone as detected with 6 × 6-mm OCT angiography and analyzed using an automated algorithm. Secondary measures included the agreement of the avascular area between the OCT angiogram and FA.ResultsCompared with the 12 healthy controls (11 women; mean [SD] age, 54.2 [14.2] years), the 12 participants with DR (4 women; mean [SD] age, 55.1 [12.1] years) had reduced parafoveal and perifoveal vessel density by 12.6% (95% CI, 7.7%-17.5%; P < .001) and 10.4% (95% CI, 6.8%-14.1%; P < .001), respectively. Total avascular area and foveal avascular zone area were greater in eyes with DR by 0.82 mm2 (95% CI, 0.65-0.99 mm2; P = .02) and 0.16 mm2 (95% CI, 0.05-0.28 mm2; P < .001). The agreement between the vascular areas in the OCT angiogram and FA had a κ value of 0.45 (95% CI, 0.21-0.70; P < .001). Total avascular area in the central 5.5-mm-diameter area distinguished eyes with DR from control eyes with 100% sensitivity and specificity.Conclusions and relevanceAvascular area analysis with an automated algorithm using OCT angiography, although not equivalent to FA, detected DR reliably in this small pilot study. Further study is necessary to determine the usefulness of the automated quantification in clinical practice.

Dataset Information

Autoimmune retinopathy: findings and limitations from optical coherence tomography angiography.

Publications

Autoimmune retinopathy: findings and limitations from optical coherence tomography angiography.

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