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Calcineurin subunit B upregulates ?-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4.

ABSTRACT: Toll-like receptors (TLRs) function as pattern-reorganization receptors in mammals and play an essential role in innate immunity. After recognizing certain ligands, TLRs activate a cascade of signal pathways to establish a guard environment. For the first time, we report that in vitro treatment with recombinant calcineurin subunit B (CNB) upregulated several TLR-related genes. Calcineurin subunit B interacted with the ectodomain of TLR4 in vitro. On further investigation, phosphorylation of interferon regulatory factor 3 and degradation of I?B-? were observed by CNB stimulation. In addition to pro-inflammatory cytokines, transcription and production of ?-interferon were also enhanced after CNB stimulation. Thus, CNB could be further explored as a cancer and virus immunotherapy drug.

SUBMITTER: Wang X 

PROVIDER: S-EPMC7713623 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Calcineurin subunit B upregulates β-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4.

Wang Xinyu X   Li Li L   Huang Yi Y   Wei Qun Q  

Cancer science 20120106 3

Toll-like receptors (TLRs) function as pattern-reorganization receptors in mammals and play an essential role in innate immunity. After recognizing certain ligands, TLRs activate a cascade of signal pathways to establish a guard environment. For the first time, we report that in vitro treatment with recombinant calcineurin subunit B (CNB) upregulated several TLR-related genes. Calcineurin subunit B interacted with the ectodomain of TLR4 in vitro. On further investigation, phosphorylation of inte  ...[more]

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