Dataset Information

How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.

ABSTRACT: Purpose: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively.

Methods: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (?). CZ was considered when ??>?4.6 (>99% of damaged cells). Regions with 0.6<??
Results: Ten-min RFA (51?W) created smaller periablational zones than 10-min MWA (11.3?cm³ vs. 17.2-22.9?cm³, for 60-100?W MWA, respectively). Prolonging duration from 5 to 10?min increased the PZ in MWA more than in RFA (2.7?cm³ for RFA vs. 8.3-11.9?cm³ for 60-100?W MWA, respectively). PZ/CZ for RFA were relatively high (65-69%), regardless of ablation time, while those for MWA were highly dependent on the duration (increase of up to 25% between 5 and 10?min) and on the applied power (smaller values as power was raised, 102% for 60?W vs. 81% for 100?W, both for 10?min). The lowest PZ/CZ across all settings was 56%, obtained with 100?W-5?min MWA.

Conclusions: Although RFA creates smaller periablational zones than MWA, 100?W-5?min MWA provides the lowest PZ/CZ.

SUBMITTER: Trujillo M

PROVIDER: S-EPMC7714001 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.

Trujillo Macarena M Prakash Punit P Faridi Pegah P Radosevic Aleksandar A Curto Sergio S Burdio Fernando F Berjano Enrique E

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20200101 1

<h4>Purpose</h4>To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively.<h4>Methods</h4>Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (<i>Ω</i>). CZ was considered when <i>Ω</i> > 4.6 (>99% of damaged cells). Regions with 0.6<< ...[more]

PMID: 32996794

Similar Datasets

Project description:ObjectivesWe aimed to compare the therapeutic outcomes of radiofrequency ablation (RFA) and microwave ablation (MWA) as first-line therapies in patients with small single perivascular hepatocellular carcinoma (HCC).MethodsA total of 144 eligible patients with small (≤ 3 cm) single perivascular (proximity to hepatic and portal veins) HCC who underwent RFA (N = 70) or MWA (N = 74) as first-line treatment were included. The overall survival (OS), disease-free survival (DFS), and local tumor progression (LTP) rates between the two ablation modalities were compared. The inverse probability of treatment weighting (IPTW) method was used to reduce selection bias. Subgroup analysis was performed according to the type of hepatic vessels.ResultsAfter a median follow-up time of 38.2 months, there were no significant differences in OS (5-year OS: RFA 77.7% vs. MWA 74.6%; p = 0.600) and DFS (5-year DFS: RFA 24.7% vs. MWA 40.4%; p = 0.570). However, a significantly higher LTP rate was observed in the RFA group than the MWA group (5-year LTP: RFA 24.3% vs. MWA 8.4%; p = 0.030). IPTW-adjusted analyses revealed similar results. The treatment modality (RFA vs. MWA: HR 7.861, 95% CI 1.642-37.635, p = 0.010) was an independent prognostic factor for LTP. We observed a significant interaction effect of ablation modality and type of peritumoral vessel on LTP (p = 0.034). For patients with periportal HCC, the LTP rate was significantly higher in the RFA group than in the MWA group (p = 0.045). However, this difference was not observed in patients with perivenous HCC (p = 0.116).ConclusionsIn patients with a small single periportal HCC, MWA exhibited better tumor control than RFA.Key points• Microwave ablation exhibited better local tumor control than radiofrequency ablation for small single periportal hepatocellular carcinoma. • There was a significant interaction between the treatment effect of ablation modality and type of peritumoral vessel on local tumor progression. • The type of peritumoral vessel is vital in choosing ablation modalities for hepatocellular carcinoma.

Dataset Information

How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.

Publications

How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets