An unhealing wound and subcutaneous nodules due to Sporothrix globosa after a cat bite.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7714111 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
An unhealing wound and subcutaneous nodules due to Sporothrix globosa after a cat bite.
Liu Yanbin Y Liu Lina L Kang Mei M Zong Zhiyong Z
PLoS neglected tropical diseases 20201203 12
A 51-year-old man with 3-month unhealing cat bite wound was diagnosed with sporotrichosis, a subacute-to-chronic infection caused by the worldwide endemic, dimorphic fungus Sporothrix globosa. The case would help clinicians to raise awareness of human sporotrichosis due to cat bites, which remains rare and is likely to be underrecognized and misdiagnosed. ...[more]
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Project description:Sporothrix schenckii is the species responsible for sporotrichosis, a fungal infection caused by the traumatic implantation of this dimorphic fungus. Recent molecular studies have demonstrated that this species constitutes a complex of numerous phylogenetic species. Since the delineation of such species could be of extreme importance from a clinical point of view, we have studied a total of 127 isolates, most of which were received as S. schenckii, including the available type strains of species currently considered synonyms, and also some close morphological species. We have phenotypically characterized all these isolates using different culture media, growth rates at different temperatures, and numerous nutritional tests and compared their calmodulin gene sequences. The molecular analysis revealed that Sporothrix albicans, S. inflata, and S. schenckii var. luriei are species that are clearly different from S. schenckii. The combination of these phenetic and genetic approaches allowed us to propose the new species Sporothrix brasiliensis, S. globosa, and S. mexicana. The key phenotypic features for recognizing these species are the morphology of the sessile pigmented conidia, growth at 30, 35, and 37 degrees C, and the assimilation of sucrose, raffinose, and ribitol.
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| S-EPMC6394905 | biostudies-literature
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| PRJNA590592 | ENA