Identification of unrecognized host factors promoting HIV-1 latency.
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ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7714144 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Identification of unrecognized host factors promoting HIV-1 latency.
Li Zichong Z Hajian Cyrus C Greene Warner C WC
PLoS pathogens 20201203 12
To counter HIV latency, it is important to develop a better understanding of the full range of host factors promoting latency. Their identification could suggest new strategies to reactivate latent proviruses and subsequently kill the host cells ("shock and kill"), or to permanently silence these latent proviruses ("block and lock"). We recently developed a screening strategy termed "Reiterative Enrichment and Authentication of CRISPRi Targets" (REACT) that can unambiguously identify host genes ...[more]
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2021-11-22 | GSE189314 | GEO
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2019-06-04 | GSE132138 | GEO