Dataset Information

Corneal thickness evaluation in healthy eyes: Comparison between two different Scheimpflug devices.

ABSTRACT: Purpose: To evaluate the correlation between corneal thickness (CT) measurements obtained with two Scheimpflug devices, Pentacam HR and Precisio, and to elaborate, if necessary, a regression formula which could make these results comparable.

Design: Retrospective, Comparative, Observational study.

Setting: Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Italy.

Methods: One hundred twenty four healthy eyes of 124 volunteers (65 males; range: 20-32 years; mean age of 24.8 ± 1.7) were included in this study. CT was measured using Pentacam HR and Precisio in three different points: the pupil center (PC), the corneal apex (CA) and the thinnest point (TP).

Results: CT obtained with both devices at the PC, at the CA and at the TP showed a good correlation (r = 0.97, r = 0.97, r = 0.97, respectively), but Pentacam HR measurements were significantly thicker than those provided by Precisio (p < 0.01). The differences between Pentacam HR and Precisio were 21.9 ± 8.8 ?m at the PC, 21.9 ± 8.9 ?m at the CA, 19.1 ± 9.0 ?m at the TP. The calculated regression formulas were: y = 0.9558x + 2.3196 for the PC, y = 0.9519x + 4.5626 for the CA, y = 0.9364x + 15.436 for the TP, where x is the CT measured with Pentacam HR and y is the Precisio measurement.

Conclusions: The findings provided by this study highlight that Precisio measures thinner corneas compared to Pentacam HR. The identified regression formulas could be utilized to make interchangeable the results obtained with these two devices.

SUBMITTER: Rosa N

PROVIDER: S-EPMC7714349 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Corneal thickness evaluation in healthy eyes: Comparison between two different Scheimpflug devices.

Rosa Nicola N De Bernardo Maddalena M Pepe Angela A Vitiello Livio L Marotta Giuseppe G Imparato Roberto R Capasso Luigi L

PloS one 20201203 12

<h4>Purpose</h4>To evaluate the correlation between corneal thickness (CT) measurements obtained with two Scheimpflug devices, Pentacam HR and Precisio, and to elaborate, if necessary, a regression formula which could make these results comparable.<h4>Design</h4>Retrospective, Comparative, Observational study.<h4>Setting</h4>Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Italy.<h4>Methods</h4>One hundred twenty four healthy eyes of 124 volunteer ...[more]

PMID: 33270786

Similar Datasets

Project description:ObjectiveTo map the corneal epithelial thickness with Fourier-domain optical coherence tomography (OCT) and to develop epithelial thickness-based variables for keratoconus detection.DesignCross-sectional observational study.ParticipantsOne hundred forty-five eyes from 76 normal subjects and 35 keratoconic eyes from 22 patients.MethodsA 26,000-Hz Fourier-domain OCT system with 5-?m axial resolution was used. The cornea was imaged with a Pachymetry + Cpwr scan pattern (6-mm scan diameter, 8 radials, 1024 axial-scans each, repeated 5 times) centered on the pupil. Three scans were obtained at a single visit in a prospective study. A computer algorithm was developed to map the corneal epithelial thickness automatically. Zonal epithelial thicknesses and 5 diagnostic variables, including minimum, superior-inferior (S-I), minimum-maximum (MIN-MAX), map standard deviation (MSD), and pattern standard deviation (PSD), were calculated. Repeatability of the measurements was assessed by the pooled standard deviation. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy.Main outcome measuresDescriptive statistics, repeatability, and AUC of the zonal epithelial thickness and diagnostic variables.ResultsThe central, superior, and inferior epithelial thickness averages were 52.3 ± 3.6 ?m, 49.6 ± 3.5 ?m, and 51.2 ± 3.4 ?m in normal eyes and 51.9 ± 5.3 ?m, 51.2 ± 4.2 ?m, and 49.1 ± 4.3 ?m in keratoconic eyes. Compared with normal eyes, keratoconic eyes had significantly lower inferior (P = 0.03) and minimum (P<0.0001) corneal epithelial thickness, greater S-I (P = 0.013), more negative MIN-MAX (P<0.0001), greater MSD (P<0.0001), and larger PSD (P<0.0001). The repeatability of the zonal average, minimum, S-I, and MIN-MAX epithelial thickness variables were between 0.7 and 1.9 ?m. The repeatability of MSD was better than 0.4 ?m. The repeatability of PSD was 0.02 or better. Among all epithelial thickness-based variables investigated, PSD provided the best diagnostic power (AUC = 1.00). Using an PSD cutoff value of 0.057 alone gave 100% specificity and 100% sensitivity.ConclusionsHigh-resolution Fourier-domain OCT mapped corneal epithelial thickness with good repeatability in both normal and keratoconic eyes. Keratoconus was characterized by apical epithelial thinning. The resulting deviation from the normal epithelial pattern could be detected with very high accuracy using the PSD variable.Financial disclosure(s)Proprietary or commercial disclosure may be found after the references.

Dataset Information

Corneal thickness evaluation in healthy eyes: Comparison between two different Scheimpflug devices.

Publications

Corneal thickness evaluation in healthy eyes: Comparison between two different Scheimpflug devices.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets