Ontology highlight
ABSTRACT:
SUBMITTER: Shaw J
PROVIDER: S-EPMC7714397 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
eLife 20201110
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or 'viroporins', contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamantane inhibitors of the influenza A virus (IAV) M2 proton channel, a growing number of clinically and economically important viruses are now recognised to encode essential viroporins providing potential targets for modern drug discovery. We describe the fir ...[more]