Ontology highlight
ABSTRACT:
SUBMITTER: Beiersdorf J
PROVIDER: S-EPMC7714410 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Beiersdorf Johannes J Hevesi Zsofia Z Calvigioni Daniela D Pyszkowski Jakob J Romanov Roman R Szodorai Edit E Lubec Gert G Shirran Sally S Botting Catherine H CH Kasper Siegfried S Guy Geoffrey W GW Gray Roy R Di Marzo Vincenzo V Harkany Tibor T Keimpema Erik E
JCI insight 20201203 23
Ongoing societal changes in views on the medical and recreational roles of cannabis increased the use of concentrated plant extracts with a Δ9-tetrahydrocannabinol (THC) content of more than 90%. Even though prenatal THC exposure is widely considered adverse for neuronal development, equivalent experimental data for young age cohorts are largely lacking. Here, we administered plant-derived THC (1 or 5 mg/kg) to mice daily during P5-P16 and P5-P35 and monitored its effects on hippocampal neuronal ...[more]