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Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer.

ABSTRACT: Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (P = 0.001) and American Joint Committee on Cancer (AJCC) stage (P = 0.013). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.

SUBMITTER: Feng X

PROVIDER: S-EPMC7714607 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer.

Feng Xiaodong X Zhang Zhijun Z Sun Peng P Song Guanghui G Wang Lu L Sun Zhenqing Z Yuan Ning N Wang Qing Q Lun Limin L

Disease markers 20201126

Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (<i>P</i> = 0.001) and American Joint Committee on Cancer (AJCC) stage (<i>P</i> = 0.0 ...[more]

PMID: 33294056

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