Impact of proton radiotherapy on treatment timing in pediatric and adult patients with CNS tumors.

ABSTRACT:

Background

Despite putative benefits associated with proton radiotherapy in the setting of CNS tumors, numerous barriers limit treatment accessibility. Given these challenges, we explored the association of proton use with variations in treatment timing.

Methods

Pediatric and adult patients with histologically confirmed CNS tumors were identified from the National Cancer Database (2004-2015). Univariable and multivariable regression models were constructed to assess factors impacting radiation timing. Multivariable Cox regression was used to evaluate the effect of treatment delay on survival.

Results

A total of 76 157 patients received photon or proton radiotherapy. Compared to photons, time to proton administration was longer in multiple pediatric (embryonal, ependym

SUBMITTER: Jin MC 

PROVIDER: S-EPMC7716142 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature