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Tenascin C promotes valvular remodeling in two large animal models of ischemic mitral regurgitation.


ABSTRACT: Ischemic mitral regurgitation (MR) is a frequent complication of myocardial infarction (MI) characterized by adverse remodeling both at the myocardial and valvular levels. Persistent activation of valvular endothelial cells leads to leaflet fibrosis through endothelial-to-mesenchymal transition (EMT). Tenascin C (TNC), an extracellular matrix glycoprotein involved in cardiovascular remodeling and fibrosis, was also identified in inducing epithelial-to-mesenchymal transition. In this study, we hypothesized that TNC also plays a role in the valvular remodeling observed in ischemic MR by contributing to valvular excess EMT. Moderate ischemic MR was induced by creating a posterior papillary muscle infarct (7 pigs and 7 sheep). Additional animals (7 pigs and 4 sheep) served as controls. Pigs and sheep were sacrificed after 6 weeks and 6 months, respectively. TNC expression was upregulated in the pig and sheep experiments at 6 weeks and 6 months, respectively, and correlated well with leaflet thickness (R?=?0.68; p?

SUBMITTER: Hamza O 

PROVIDER: S-EPMC7716900 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Tenascin C promotes valvular remodeling in two large animal models of ischemic mitral regurgitation.

Hamza Ouafa O   Kiss Attila A   Kramer Anne-Margarethe AM   Trojanek Sandra S   Abraham Dietmar D   Acar Eylem E   Nagel Felix F   Tretter Verena Eva VE   Kitzwögerer Melitta M   Podesser Bruno K BK  

Basic research in cardiology 20201201 6


Ischemic mitral regurgitation (MR) is a frequent complication of myocardial infarction (MI) characterized by adverse remodeling both at the myocardial and valvular levels. Persistent activation of valvular endothelial cells leads to leaflet fibrosis through endothelial-to-mesenchymal transition (EMT). Tenascin C (TNC), an extracellular matrix glycoprotein involved in cardiovascular remodeling and fibrosis, was also identified in inducing epithelial-to-mesenchymal transition. In this study, we hy  ...[more]

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