Ontology highlight
ABSTRACT:
SUBMITTER: Hamza O
PROVIDER: S-EPMC7716900 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Hamza Ouafa O Kiss Attila A Kramer Anne-Margarethe AM Trojanek Sandra S Abraham Dietmar D Acar Eylem E Nagel Felix F Tretter Verena Eva VE Kitzwögerer Melitta M Podesser Bruno K BK
Basic research in cardiology 20201201 6
Ischemic mitral regurgitation (MR) is a frequent complication of myocardial infarction (MI) characterized by adverse remodeling both at the myocardial and valvular levels. Persistent activation of valvular endothelial cells leads to leaflet fibrosis through endothelial-to-mesenchymal transition (EMT). Tenascin C (TNC), an extracellular matrix glycoprotein involved in cardiovascular remodeling and fibrosis, was also identified in inducing epithelial-to-mesenchymal transition. In this study, we hy ...[more]