Unknown

Dataset Information

0

Unconventional Secondary Structure Mimics: Ladder-Rungs.


ABSTRACT: Secondary structures tend to be recognizable because they have repeating structural motifs, but mimicry of these does not have to follow such well-defined patterns. Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole chemotype (1) to protein-protein interfaces revealed it tends to align well across parallel and antiparallel sheets, like rungs on a ladder. One set of these overlays was observed for the protein-protein interaction uPA⋅uPAR. Consequently, chemotype 1 was made with appropriate side-chains to mimic uPA at this interface. Biophysical assays indicate these compounds did in fact bind uPAR, and elicit cellular responses that affected invasion, migration, and wound healing.

SUBMITTER: Lin CM 

PROVIDER: S-EPMC7717619 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9473169 | biostudies-literature
| S-EPMC7181601 | biostudies-literature
| S-EPMC6069483 | biostudies-literature
| S-EPMC3862180 | biostudies-literature
2016-06-14 | E-MTAB-3335 | biostudies-arrayexpress
2017-06-15 | E-MTAB-4859 | biostudies-arrayexpress
| S-EPMC5512705 | biostudies-literature
| S-EPMC4964965 | biostudies-literature
| S-EPMC9221444 | biostudies-literature
| S-EPMC8598163 | biostudies-literature