Ontology highlight
ABSTRACT:
SUBMITTER: Lupanga U
PROVIDER: S-EPMC7717909 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lupanga Upendo U Röhrich Rachel R Askani Jana J Hilmer Stefan S Kiefer Christiane C Krebs Melanie M Kanazawa Takehiko T Ueda Takashi T Schumacher Karin K
eLife 20201125
The V-ATPase is a versatile proton-pump found in a range of endomembrane compartments yet the mechanisms governing its differential targeting remain to be determined. In Arabidopsis, VHA-a1 targets the V-ATPase to the TGN/EE whereas VHA-a2 and VHA-a3 are localized to the tonoplast. We report here that the VHA-a1 targeting domain serves as both an ER-exit and as a TGN/EE-retention motif and is conserved among seed plants. In contrast, Marchantia encodes a single VHA-isoform that localizes to the ...[more]