An Integrated Bioinformatic Analysis of the S100 Gene Family for the Prognosis of Colorectal Cancer.

ABSTRACT:

Background

S100 family genes exclusively encode at least 20 calcium-binding proteins, which possess a wide spectrum of intracellular and extracellular functions in vertebrates. Multiple lines of evidences suggest that dysregulated S100 proteins are associated with human malignancies including colorectal cancer (CRC). However, the diverse expression patterns and prognostic roles of distinct S100 genes in CRC have not been fully elucidated.

Methods

In the current study, we analyzed the mRNA expression levels of S100 family genes and proteins and their associations with the survival of CRC patients using the Oncomine analysis and GEPIA databases. Expressions and mutations of S100 family genes were analyzed using the cBioPortal, and protein-protein interaction (PPI) networks of

SUBMITTER: Zeng ML 

PROVIDER: S-EPMC7718059 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature