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Intraocular T-cell lymphoma metastasizing from a primary adrenal T-cell lymphoma: Case report.


ABSTRACT: Introduction: Most intraocular T-cell lymphomas arise from metastatic source. We are reporting a rare case of intraocular T-cell lymphoma masquerading as pseudo-hypopyon and vitritis. The eye involvement proved to represent a metastatic spread from a co-existing adrenal T-cell lymphoma, which was discovered after the initial ophthalmic presentation.

Presentation of case: Our patient was a 71-year-old Saudi man, who was admitted for workup of anemia and weight loss. He also noticed a gradual, painless decline in his vision of both eyes, for which he was referred to the ophthalmology unit. Ocular examination revealed left eye 3 mm pinkish hypopyon. A diagnosis of T-cell lymphoma was made based on careful microscopic examination of the left aqueous fluid, immunohistochemical (IHC) and Flow cytometry analysis. Computerized tomography showed a large invasive left adrenal mass, which has proven to be a primary adrenal lymphoma with multiple metastasis including the intraocular involvement.

Discussion: Primary intraocular lymphoma is the most common lymphoma in the eye. Intraocular T-cell lymphoma is rare and is mostly metastatic. On the other hand, primary adrenal lymphoma (especially T-cell lymphoma) is also rare. There are only 5 cases of primary adrenal lymphoma, two of which, resulted in eye metastasis similar to our case. Primary adrenal lymphoma is known to be aggressive. Our patient eventually passed away.

Conclusion: This report stresses the importance of referring patients with systemic lymphoma to an ophthalmologist to be evaluated for ocular involvement. Even though intraocular metastatic adrenal T cell lymphoma is rare, high clinical suspicion in patients who are presenting with pinkish hypopyon in the presence of other constitutional symptoms is essential.

SUBMITTER: Bedaiwi K 

PROVIDER: S-EPMC7718212 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Intraocular T-cell lymphoma metastasizing from a primary adrenal T-cell lymphoma: Case report.

Bedaiwi Khalid K   Alfawaz Abdullah M AM   Mohammed Shamayel F SF   Maktabi Azza My AM   Alqahtani Faisal F   Alhazzaa Salwa S   Alkatan Hind M HM  

Annals of medicine and surgery (2012) 20201127


<h4>Introduction</h4>Most intraocular T-cell lymphomas arise from metastatic source. We are reporting a rare case of intraocular T-cell lymphoma masquerading as pseudo-hypopyon and vitritis. The eye involvement proved to represent a metastatic spread from a co-existing adrenal T-cell lymphoma, which was discovered after the initial ophthalmic presentation.<h4>Presentation of case</h4>Our patient was a 71-year-old Saudi man, who was admitted for workup of anemia and weight loss. He also noticed a  ...[more]

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