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Saturation transfer properties of tumour xenografts derived from prostate cancer cell lines 22Rv1 and DU145.

ABSTRACT: Histopathology is currently the most reliable tool in assessing the aggressiveness and prognosis of solid tumours. However, developing non-invasive modalities for tumour evaluation remains crucial due to the side effects and complications caused by biopsy procedures. In this study, saturation transfer MRI was used to investigate the microstructural and metabolic properties of tumour xenografts in mice derived from the prostate cancer cell lines 22Rv1 and DU145, which express different aggressiveness. The magnetization transfer (MT) and chemical exchange saturation transfer (CEST) effects, which are associated with the microstructural and metabolic properties in biological tissue, respectively, were analyzed quantitatively and compared amongst different tumour types and regions. Histopathological staining was performed as a reference. Higher cellular density and metabolism expressed in more aggressive tumours (22Rv1) were associated with larger MT and CEST effects. High collagen content in the necrotic regions might explain their higher MT effects compared to tumour regions.

SUBMITTER: Tan Z

PROVIDER: S-EPMC7718243 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Saturation transfer properties of tumour xenografts derived from prostate cancer cell lines 22Rv1 and DU145.

Tan Ziyu Z Lam Wilfred W WW Oakden Wendy W Murray Leedan L Koletar Margaret M MM Liu Stanley K SK Stanisz Greg J GJ

Scientific reports 20201204 1

Histopathology is currently the most reliable tool in assessing the aggressiveness and prognosis of solid tumours. However, developing non-invasive modalities for tumour evaluation remains crucial due to the side effects and complications caused by biopsy procedures. In this study, saturation transfer MRI was used to investigate the microstructural and metabolic properties of tumour xenografts in mice derived from the prostate cancer cell lines 22Rv1 and DU145, which express different aggressive ...[more]

PMID: 33277574

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Dataset Information

Saturation transfer properties of tumour xenografts derived from prostate cancer cell lines 22Rv1 and DU145.

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Saturation transfer properties of tumour xenografts derived from prostate cancer cell lines 22Rv1 and DU145.

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