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Longitudinal analysis of total serum IgE levels with allergen sensitization and atopic diseases in early childhood.


ABSTRACT: There are few studies addressing the longitudinal analysis of serum IgE levels and its impact to the development of atopic diseases in early childhood. We investigated 170 children who regularly followed up at our clinic for 4 years in a birth cohort study with at least 3 time-points of serum samples. The pattern of total serum IgE levels from 6 months to 4 years of age was clustered using K-means method in R software. Specific immunoglobulin E antibodies against food (egg white and milk) and inhalant allergens (D. pteronyssinus and D. farinae) were measured at 0.5, 1, 1.5, 2, 3 and 4 years of age. By using K-means clustering, the dynamic changes in serum IgE levels was significantly stratified into 3 clusters (cluster A,?

SUBMITTER: Wong CY 

PROVIDER: S-EPMC7718260 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Longitudinal analysis of total serum IgE levels with allergen sensitization and atopic diseases in early childhood.

Wong Chun-Ying CY   Yeh Kuo-Wei KW   Huang Jing-Long JL   Su Kuan-Wen KW   Tsai Ming-Han MH   Hua Man-Chin MC   Liao Sui-Ling SL   Lai Shen-Hao SH   Chen Li-Chen LC   Chiu Chih-Yung CY  

Scientific reports 20201204 1


There are few studies addressing the longitudinal analysis of serum IgE levels and its impact to the development of atopic diseases in early childhood. We investigated 170 children who regularly followed up at our clinic for 4 years in a birth cohort study with at least 3 time-points of serum samples. The pattern of total serum IgE levels from 6 months to 4 years of age was clustered using K-means method in R software. Specific immunoglobulin E antibodies against food (egg white and milk) and in  ...[more]

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