Ontology highlight
ABSTRACT:
SUBMITTER: Brown JC
PROVIDER: S-EPMC7718298 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Brown Justin C JC Zhang Sui S Ligibel Jennifer A JA Irwin Melinda L ML Jones Lee W LW Campbell Nancy N Pollak Michael N MN Sorrentino Alexandra A Cartmel Brenda B Harrigan Maura M Tolaney Sara M SM Winer Eric P EP Ng Kimmie K Abrams Thomas A TA Sanft Tara T Douglas Pamela S PS Hu Frank B FB Fuchs Charles S CS Meyerhardt Jeffrey A JA
Cancer prevention research (Philadelphia, Pa.) 20200828 12
Observational studies report that physical activity and metformin are associated with improved clinical outcome in patients with cancer. Inflammation is one biological mechanism hypothesized to mediate these associations. In this phase II, multicenter, 2 × 2 factorial trial, 139 patients with breast and colorectal cancer who completed standard therapy were randomized to one of four treatment groups for 12 weeks: exercise alone, metformin alone, exercise and metformin, or control. Inflammation ou ...[more]