Dataset Information

Development of fast multi-slice apparent T₁ mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

ABSTRACT:

Purpose

To develop fast multi-slice apparent T₁ (T_1app ) mapping for accurate cerebral blood flow (CBF) quantification with arterial spin labeling (ASL) MRI.

Methods

Fast multi-slice T_1app was measured using a modified inversion recovery echo planar imaging (EPI) sequence with simultaneous application of ASL tagging radiofrequency (RF) and gradient pulses. The fast multi-slice T_1app measurement was compared with the single-slice T_1app imaging approach, repeated per slice. CBF was assessed in healthy adult Wistar rats (N = 5) and rats with acute stroke 24 hours after a transient middle cerebral artery occlusion (N = 5).

Results

The fast multi-slice T_1app measurement was in good agreement with that of a single-slice T_1app imaging approach (Lin's concordance correlation coefficient = 0.92). CBF calculated using T_1app reasonably accounted for the finite labeling RF duration, whereas the routine T₁ -normalized ASL MRI underestimated the CBF, particularly at short labeling durations. In acute stroke rats, the labeling time and the CBF difference (ΔCBF) between the contralateral normal area and the ischemic lesion were significantly correlated when using T₁ -normalized perfusion calculation (R = 0.844, P = .035). In comparison, T_1app -normalized ΔCBF had little labeling time dependence based on the linear regression equation of ΔCBF = -0.0247*τ + 1.579 mL/g/min (R = -0.352, P = .494).

Conclusions

Our study found fast multi-slice T_1app imaging improves the accuracy and reproducibility of CBF measurement.

SUBMITTER: Ji Y

PROVIDER: S-EPMC7718392 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Development of fast multi-slice apparent T<sub>1</sub> mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

Ji Yang Y Lu Dongshuang D Jiang Yinghua Y Wang Xiaoying X Meng Yuguang Y Sun Phillip Zhe PZ

Magnetic resonance in medicine 20200924 3

<h4>Purpose</h4>To develop fast multi-slice apparent T<sub>1</sub> (T<sub>1app</sub> ) mapping for accurate cerebral blood flow (CBF) quantification with arterial spin labeling (ASL) MRI.<h4>Methods</h4>Fast multi-slice T<sub>1app</sub> was measured using a modified inversion recovery echo planar imaging (EPI) sequence with simultaneous application of ASL tagging radiofrequency (RF) and gradient pulses. The fast multi-slice T<sub>1app</sub> measurement was compared with the single-slice T<sub>1a ...[more]

PMID: 32970848

Similar Datasets

Project description:BackgroundArterial spin labeling (ASL) perfusion-weighted imaging (PWI) by magnetic resonance imaging (MRI) has been shown to be useful for identifying asphyxiated newborns at risk of developing brain injury, whether or not therapeutic hypothermia was administered. However, this technique has been only rarely used in newborns until now, because of the challenges to obtain sufficient signal-to-noise ratio (SNR) and spatial resolution in newborns.ObjectiveTo compare two methods of ASL-PWI (i.e., single inversion-time pulsed arterial spin labeling [single TI PASL], and pseudo-continuous arterial spin labeling [pCASL]) to assess brain perfusion in asphyxiated newborns treated with therapeutic hypothermia and in healthy newborns.Design/methodsWe conducted a prospective cohort study of term asphyxiated newborns meeting the criteria for therapeutic hypothermia; four additional healthy term newborns were also included as controls. Each of the enrolled newborns was scanned at least once during the first month of life. Each MRI scan included conventional anatomical imaging, as well as PASL and pCASL PWI-MRI. Control and labeled images were registered separately to reduce the effect of motion artifacts. For each scan, the axial slice at the level of the basal ganglia was used for comparisons. Each scan was scored for its image quality. Quantification of whole-slice cerebral blood flow (CBF) was done afterwards using previously described formulas.ResultsA total number of 61 concomitant PASL and pCASL scans were obtained in nineteen asphyxiated newborns treated with therapeutic hypothermia and four healthy newborns. After discarding the scans with very poor image quality, 75% (46/61) remained for comparison between the two ASL methods. pCASL images presented a significantly superior image quality score compared to PASL images (p < 0.0001). Strong correlation was found between the CBF measured by PASL and pCASL (r = 0.61, p < 0.0001).ConclusionThis study demonstrates that both ASL methods are feasible to assess brain perfusion in healthy and sick newborns. However, pCASL might be a better choice over PASL in newborns, as pCASL perfusion maps had a superior image quality that allowed a more detailed identification of the different brain structures.

Dataset Information

Development of fast multi-slice apparent T₁ mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

Purpose

Methods

Results

Conclusions

Publications

Development of fast multi-slice apparent T<sub>1</sub> mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Development of fast multi-slice apparent T1 mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

Purpose

Methods

Results

Conclusions

Publications

Development of fast multi-slice apparent T<sub>1</sub> mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Development of fast multi-slice apparent T₁ mapping for improved arterial spin labeling MRI measurement of cerebral blood flow.