Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer.
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ABSTRACT:
SUBMITTER: Moslehi R
PROVIDER: S-EPMC7718875 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer.
Moslehi Roxana R Tsao Hui-Shien HS Zeinomar Nur N Stagnar Cristy C Fitzpatrick Sean S Dzutsev Amiran A
Scientific reports 20201204 1
Up to 30% of all breast cancer cases may be inherited and up to 85% of those may be due to segregation of susceptibility genes with low and moderate risk [odds ratios (OR) ≤ 3] for (mostly peri- and post-menopausal) breast cancer. The majority of low/moderate-risk genes, particularly those with minor allele frequencies (MAF) of < 30%, have not been identified and/or validated due to limitations of conventional association testing approaches, which include the agnostic nature of Genome Wide Assoc ...[more]
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