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Facile Discovery and Quantification of Isonitrile Natural Products via Tetrazine-Based Click Reactions.


ABSTRACT: A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. This method was successfully applied to the rediscovery of diisonitrile antibotic SF2768 from an unknown strain Streptomyces tsukubensis. Finally, an in situ reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time.

SUBMITTER: Huang YB 

PROVIDER: S-EPMC7718942 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Facile Discovery and Quantification of Isonitrile Natural Products via Tetrazine-Based Click Reactions.

Huang Yao-Bing YB   Cai Wenlong W   Del Rio Flores Antonio A   Twigg Frederick F FF   Zhang Wenjun W  

Analytical chemistry 20191211 1


A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. This method was successfully applied to the rediscovery of diisonitrile antibotic SF2768 from an unknown strain <i>Streptomyces tsukubensis</i>. Finally, an <i>in situ</i> reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time. ...[more]

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