Ontology highlight
ABSTRACT:
SUBMITTER: Huang YB
PROVIDER: S-EPMC7718942 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Huang Yao-Bing YB Cai Wenlong W Del Rio Flores Antonio A Twigg Frederick F FF Zhang Wenjun W
Analytical chemistry 20191211 1
A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. This method was successfully applied to the rediscovery of diisonitrile antibotic SF2768 from an unknown strain <i>Streptomyces tsukubensis</i>. Finally, an <i>in situ</i> reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time. ...[more]