Alleviating Cellular Oxidative Stress through Treatment with Superoxide-Triggered Persulfide Prodrugs.

ABSTRACT: Overproduction of superoxide anion (O₂^.- ), the primary cellular reactive oxygen species (ROS), is implicated in various human diseases. To reduce cellular oxidative stress caused by overproduction of superoxide, we developed a compound that reacts with O₂^.- to release a persulfide (RSSH), a type of reactive sulfur species related to the gasotransmitter hydrogen sulfide (H₂ S). Termed SOPD-NAC, this persulfide donor reacts specifically with O₂^.- , decomposing to generate N-acetyl cysteine (NAC) persulfide. To enhance persulfide delivery to cells, we conjugated the SOPD motif to a short, self-assembling peptide (Bz-CFFE-NH₂ ) to make a superoxide-responsive, persulfide-donating peptide (SOPD-Pep). Both S

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7719095 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature