Ontology highlight
ABSTRACT:
SUBMITTER: Sun N
PROVIDER: S-EPMC7719147 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Sun Nan N Jiang Li L Ye Miaomiao M Wang Yihan Y Wang Guangwen G Wan Xiaopeng X Zhao Yuhui Y Wen Xia X Liang Libin L Ma Shujie S Liu Liling L Bu Zhigao Z Chen Hualan H Li Chengjun C
Protein & cell 20200619 12
Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon (IFN) in response to viral infection. Trim35-deficient mice were more susceptible to influenza A virus (IAV) infection than were wild-type mice. TRIM35 promoted the RIG-I-mediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 ...[more]