Ontology highlight
ABSTRACT:
SUBMITTER: Venkanna A
PROVIDER: S-EPMC7719162 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20201204 1
In-house 1,5-oxaza spiroquinone 1, with spiro[5.5]undeca ring system, was announced as an unprecedented anti-inflammatory scaffold through chemistry-oriented synthesis (ChOS), a chemocentric approach. Herein, we studied how to best position the spiro[5.5]undeca ring system in kinase inhibitor space. Notably, late-stage modification of the scaffold 1 into compounds 2a-r enhanced kinase-likeness of the scaffold 1. The improvement could be depicted with (1) selectivity with target shift (from JNK-1 ...[more]