Ontology highlight
ABSTRACT:
SUBMITTER: Jenkins ML
PROVIDER: S-EPMC7719173 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Jenkins Meredith L ML Harris Noah J NJ Dalwadi Udit U Fleming Kaelin D KD Ziemianowicz Daniel S DS Rafiei Atefeh A Martin Emily M EM Schriemer David C DC Yip Calvin K CK Burke John E JE
Communications biology 20201204 1
The TRAnsport Protein Particle (TRAPP) complexes act as Guanine nucleotide exchange factors (GEFs) for Rab GTPases, which are master regulators of membrane trafficking in eukaryotic cells. In metazoans, there are two large multi-protein TRAPP complexes: TRAPPII and TRAPPIII, with the TRAPPII complex able to activate both Rab1 and Rab11. Here we present detailed biochemical characterisation of Rab-GEF specificity of the human TRAPPII complex, and molecular insight into Rab binding. GEF assays of ...[more]