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ABSTRACT: Background
Although adjuvant transcatheter arterial chemoembolization (TACE) has been used to prevent recurrence after surgery in patients with hepatocellular carcinoma (HCC), the survival benefits from adjuvant TACE remain controversial. We sought to systematically evaluate the data on the effectiveness of adjuvant TACE for HCC, as well as identify patient populations that might benefit from adjuvant TACE.Methods
The PubMed, Embase, Medline and Cochrane library were systematically searched for studies published before July 2019 that compared adjuvant TACE versus surgery alone for HCC. The study endpoints were overall survival (OS) and disease-free survival (DFS). Patients with large HCC (?5?cm), multinodular HCC, microvascular invasion (MVI), or portal vein tumor thrombosis (PVTT) were analyzed in subgroup analyses.Results
Twenty-four studies with 6977 patients were included in the analytic cohort. The pooled analysis demonstrated that adjuvant TACE was associated with a better OS and DFS [hazard ratio (HR): 0.67 and 0.67, both p?p?p?p?ConclusionPostoperative adjuvant TACE may be effective to improve OS and DFS in patients with multinodular HCC, or HCC with MVI or PVTT. Future randomized controlled trials are needed to better define the benefit of adjuvant TACE in subset patients with HCC.
SUBMITTER: Liang L
PROVIDER: S-EPMC7720303 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liang Lei L Li Chao C Diao Yong-Kang YK Jia Hang-Dong HD Xing Hao H Pawlik Timothy M TM Lau Wan Yee WY Shen Feng F Huang Dong-Sheng DS Zhang Cheng-Wu CW Yang Tian T Yang Tian T
Therapeutic advances in gastroenterology 20201203
<h4>Background</h4>Although adjuvant transcatheter arterial chemoembolization (TACE) has been used to prevent recurrence after surgery in patients with hepatocellular carcinoma (HCC), the survival benefits from adjuvant TACE remain controversial. We sought to systematically evaluate the data on the effectiveness of adjuvant TACE for HCC, as well as identify patient populations that might benefit from adjuvant TACE.<h4>Methods</h4>The PubMed, Embase, Medline and Cochrane library were systematical ...[more]