Polymorphisms of TGF-?1 and TGF-?3 in Chinese women with gestational diabetes mellitus.

ABSTRACT: Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-? (TGF-?) superfamily play key roles in the homeostasis of pancreatic ?-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-?1, TGF-?3 and the risk to GDM in Chinese women.

Methods: This study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the TGF-?1 (rs4803455) and TGF-?3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.

Results: An increased frequency of TGF-?3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG?+?GG: ?²?=?6.314, P?=?0.012, OR?=?1.270, 95%CI 1.054-1.530; AG vs. GG?+?AA: ?²?=?8.545, P?=?0.003, OR?=?0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-?1 rs4803455 and TGF-?3 rs3917201 between GDM and healthy women. In addition, no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE).

Conclusions: The AA and AG genotype of TGF-?3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7720537 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature