Glycemic control and diabetic foot ulcer outcomes: A systematic review and meta-analysis of observational studies.

ABSTRACT:

Objective

To evaluate the association between glycemic control (hemoglobin A1C, fasting glucose, and random glucose) and the outcomes of wound healing and lower extremity amputation (LEA) among patients with diabetic foot ulcers (DFUs).

Research design and methods

Medline, EMBASE, Cochrane Library, and Scopus were searched for observational studies published up to March 2019. Five independent reviewers assessed in duplicate the eligibility of each study based on predefined eligibility criteria and two independent reviewers assessed risk of bias. Ameta-analysis was performed to calculate a pooled odds ratio (OR) or hazard ratio (HR) using random effects for glycemic measures in relation to the outcomes of wound healing and LEA. Subgroup analyses were conducted to explore pote

SUBMITTER: Lane KL 

PROVIDER: S-EPMC7721205 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature