Ontology highlight
ABSTRACT:
SUBMITTER: Kim SY
PROVIDER: S-EPMC7721357 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kim Sun Young SY Kim Donggyu D Kim Sojin S Lee Daeun D Mun Seok-Jun SJ Cho Euni E Son Wooic W Jang Kiseok K Yang Chul-Su CS
EMBO molecular medicine 20201201 12
The Rv2626c protein of Mycobacterium tuberculosis is a promising vaccine candidate owing to its strong serum antibody response in patients with tuberculosis. However, there is limited information regarding the intracellular response induced by Rv2626c in macrophages. In this study, we demonstrated that Rv2626c interacts with the RING domain of TRAF6 and inhibits lysine (K) 63-linked polyubiquitination of TRAF6 (E3 ubiquitin ligase activity); this results in the suppression of TLR4 inflammatory s ...[more]