Ontology highlight
ABSTRACT:
SUBMITTER: Tao W
PROVIDER: S-EPMC7721366 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Tao Weiwei W Zhang Aili A Zhai Kui K Huang Zhi Z Huang Haidong H Zhou Wenchao W Huang Qian Q Fang Xiaoguang X Prager Briana C BC Wang Xiuxing X Wu Qiulian Q Sloan Andrew E AE Ahluwalia Manmeet S MS Lathia Justin D JD Yu Jennifer S JS Rich Jeremy N JN Bao Shideng S
EMBO molecular medicine 20201030 12
Nuclear matrix-associated proteins (NMPs) play critical roles in regulating chromatin organization and gene transcription by binding to the matrix attachment regions (MARs) of DNA. However, the functional significance of NMPs in glioblastoma (GBM) progression remains unclear. Here, we show that the Special AT-rich Binding Protein-2 (SATB2), one of crucial NMPs, recruits histone acetyltransferase CBP to promote the FOXM1-mediated cell proliferation and tumor growth of GBM. SATB2 is preferentially ...[more]