Ontology highlight
ABSTRACT:
SUBMITTER: Marcaida MJ
PROVIDER: S-EPMC7721647 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Marcaida Maria J MJ Kauzlaric Annamaria A Duperrex Alice A Sülzle Jenny J Moncrieffe Martin C MC Adebajo Damilola D Manley Suliana S Trono Didier D Dal Peraro Matteo M
iScience 20201118 12
Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases. Currently, whether and how oligomerization impacts their biochemical and biological functions is not well understood. In this work, we show that DDX21, a human DEAD-box helicase with RNA G-quadruplex resolving activity, is dimeric and that its oligomerization state influences its helicase activity. Solution small-angle X-ray scat ...[more]