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Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography.


ABSTRACT: Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging with a resolution of <200?µm, <1?ms using a non-penetrating flexible nerve cuff electrode array. Here, we validate EIT imaging in rat sciatic nerve by comparison to micro-computed tomography (microCT) and histology with fluorescent dextran tracers. With EIT, there are reproducible localized changes in tissue impedance in response to stimulation of individual fascicles (tibial, peroneal and sural). The reconstructed EIT images correspond to microCT scans and histology, with significant separation between the fascicles (p?

SUBMITTER: Ravagli E 

PROVIDER: S-EPMC7721735 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography.

Ravagli Enrico E   Mastitskaya Svetlana S   Thompson Nicole N   Iacoviello Francesco F   Shearing Paul R PR   Perkins Justin J   Gourine Alexander V AV   Aristovich Kirill K   Holder David D  

Nature communications 20201207 1


Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging with a resolution of <200 µm, <1 ms using a non-penetrating flexible nerve cuff electrode array. Here, we validate EIT imaging in rat sciatic nerve by comparison to micro-computed  ...[more]

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