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Mesalazine granule formulation improves clinical data in Crohn's disease compared with tablet formulation.


ABSTRACT: The efficacy of sustained-release preparations of mesalazine as a remission maintenance treatment for Crohn's disease remains to be established. We aimed to examine the changes in compliance rate and clinical data 2 years after switching from mesalazine tablet to granule formulation at our facility among patients with Crohn's disease in remission. We investigated the rate of continuous treatment of mesalazine granules and examined the changes in Crohn's Disease Activity Index (CDAI) and serum C-reactive protein (CRP), albumin, and hemoglobin (Hb) levels 2 years after the switch. Compliance rate (continuous treatment vs. additional treatment) and continuous treatment rate [good (rate of???70%) vs. poor (rate?

SUBMITTER: Tamura S 

PROVIDER: S-EPMC7721736 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Mesalazine granule formulation improves clinical data in Crohn's disease compared with tablet formulation.

Tamura Satoshi S   Ishida Natsuki N   Miyazu Takahiro T   Onoue Shunya S   Tani Shinya S   Yamade Mihoko M   Hamaya Yasushi Y   Iwaizumi Moriya M   Osawa Satoshi S   Furuta Takahisa T   Sugimoto Ken K  

Scientific reports 20201207 1


The efficacy of sustained-release preparations of mesalazine as a remission maintenance treatment for Crohn's disease remains to be established. We aimed to examine the changes in compliance rate and clinical data 2 years after switching from mesalazine tablet to granule formulation at our facility among patients with Crohn's disease in remission. We investigated the rate of continuous treatment of mesalazine granules and examined the changes in Crohn's Disease Activity Index (CDAI) and serum C-  ...[more]

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