Ontology highlight
ABSTRACT:
SUBMITTER: Rovito D
PROVIDER: S-EPMC7721737 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Rovito Daniela D Belorusova Anna Y AY Chalhoub Sandra S Rerra Anna-Isavella AI Guiot Elvire E Molin Arnaud A Linglart Agnès A Rochel Natacha N Laverny Gilles G Metzger Daniel D
Nature communications 20201207 1
The bioactive vitamin D<sub>3</sub>, 1α,25(OH)<sub>2</sub>D<sub>3</sub>, plays a central role in calcium homeostasis by controlling the activity of the vitamin D receptor (VDR) in various tissues. Hypercalcemia secondary to high circulating levels of vitamin D<sub>3</sub> leads to hypercalciuria, nephrocalcinosis and renal dysfunctions. Current therapeutic strategies aim at limiting calcium intake, absorption and resorption, or 1α,25(OH)<sub>2</sub>D<sub>3</sub> synthesis, but are poorly efficie ...[more]