Dataset Information

Highly conformal reirradiation in patients with prior oropharyngeal radiation: Clinical efficacy and toxicity outcomes.

ABSTRACT:

Background

Reirradiation of head and neck cancer is associated with high rates of locoregional failure and potentially severe treatment-related toxicity. We report our institutional experience of reirradiation using modern highly conformal radiotherapy approaches in patients with prior oropharyngeal radiation.

Methods

We reviewed patients receiving curative-intent reirradiation with intensity-modulated radiation therapy, stereotactic body radiation therapy, and proton beam radiotherapy at our institution from 1999 to 2019. Disease control, survival, and toxicity rates following reirradiation were determined.

Results

Sixty-nine patients were evaluated. Local control (LC), progression-free survival, and overall survival at 2 years following reirradiation were 77%, 35%, and 51%, respectively. Grade 3 or greater (G3+) late toxicities occurred in 46% of patients and 41% required feeding tube placement during or after reirradiation.

Conclusions

In select patients with prior oropharyngeal radiation, highly conformal reirradiation offers acceptable LC, but G3+ toxicity and out-of-field failure rates remain high. These findings warrant continued evaluation of new multimodality approaches to improve oncologic outcomes.

SUBMITTER: Bagley AF

PROVIDER: S-EPMC7722120 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Highly conformal reirradiation in patients with prior oropharyngeal radiation: Clinical efficacy and toxicity outcomes.

Bagley Alexander F AF Garden Adam S AS Reddy Jay P JP Moreno Amy C AC Frank Steven J SJ Rosenthal David I DI Morrison William H WH Gunn Gary Brandon GB Fuller Clifton D CD Shah Shalin J SJ Ferrarotto Renata R Sturgis Erich M EM Gross Neil D ND Phan Jack J

Head & neck 20200809 11

<h4>Background</h4>Reirradiation of head and neck cancer is associated with high rates of locoregional failure and potentially severe treatment-related toxicity. We report our institutional experience of reirradiation using modern highly conformal radiotherapy approaches in patients with prior oropharyngeal radiation.<h4>Methods</h4>We reviewed patients receiving curative-intent reirradiation with intensity-modulated radiation therapy, stereotactic body radiation therapy, and proton beam radioth ...[more]

PMID: 32776401

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Dataset Information

Highly conformal reirradiation in patients with prior oropharyngeal radiation: Clinical efficacy and toxicity outcomes.

Background

Methods

Results

Conclusions

Publications

Highly conformal reirradiation in patients with prior oropharyngeal radiation: Clinical efficacy and toxicity outcomes.

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