Ontology highlight
ABSTRACT:
SUBMITTER: Olsen MV
PROVIDER: S-EPMC7722204 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Olsen Markus V MV Lyngstadaas Anne V AV Bair Jeffrey A JA Hodges Robin R RR Utheim Tor P TP Serhan Charles N CN Dartt Darlene A DA
Journal of cellular physiology 20200608 1
Mucin secretion from conjunctival goblet cells forms the tear film mucin layer and requires regulation to function properly. Maresin 1 (MaR1) is a specialized proresolving mediator produced during the resolution of inflammation. We determined if MaR1 stimulates mucin secretion and signaling pathways used. Cultured rat conjunctival goblet cells were used to measure the increase in intracellular Ca<sup>2+</sup> ([Ca<sup>2</sup><sup>+</sup> ]<sub>i</sub> ) concentration and mucin secretion. MaR1-in ...[more]