Correction and optimization of symmetric echo-planar spectroscopic imaging for hyperpolarized [1-¹³C]-pyruvate.

ABSTRACT: Symmetric echo-planar spectroscopic imaging (EPSI) supports higher spectral bandwidth and improves signal-to-noise efficiency compared to flyback EPSI with the same readout bandwidth, but suffers from artifacts that are associated with non-uniform temporal sampling in k-t space. Our goal is to eliminate these artifacts and enhance observation of hyperpolarized [1-¹³C] pyruvate and its metabolites using symmetric EPSI. We used symmetric EPSI to efficiently acquire radially encoded spectroscopic imaging projections with a spectral under-sampling scheme that was optimized for HP pyruvate and its metabolites. A simple approach called selective correction of off-resonance effects (SCORE) was developed and applied to eliminate spectral artifacts. Simulations were used to assess the re

SUBMITTER: Xu Z 

PROVIDER: S-EPMC7722237 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature