Dataset Information
Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes.
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ABSTRACT:
Methods: Newly diagnosed pulmonary TB patients with or without DM (TB n?=?40; TB-DM n?=?40) were recruited in Dhaka, Bangladesh. Clinical symptoms, sputum smear and culture conversion as well as chest radiography were assessed. Peripheral blood and sputum samples were collected at the time of diagnosis (baseline) and after 1, 2 and 6?months of standard anti-TB treatment. Blood samples were also obtained from healthy controls (n?=?20). mRNA expression of inflammatory markers in blood and sputum samples were quantified using real-time PCR.
Results: The majority of TB-DM patients had poor glycemic control (HbA1c?>?8%) and displayed elevated pulmonary pathology (P?=?0.039) particularly in the middle (P?
Conclusion: Insufficient up-regulation of IL-10 in the lung may fuel persistent local inflammation thereby promoting lung pathology in TB-DM patients with poorly controlled DM.
SUBMITTER: Mily A
PROVIDER: S-EPMC7722325 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes.
BMC infectious diseases 20201207 1
<h4>Background</h4>Diabetes mellitus type 2 (DM) may impede immune responses in tuberculosis (TB) and thus contribute to enhanced disease severity. In this study, we aimed to evaluate DM-mediated alterations in clinical, radiological and immunological outcomes in TB disease.<h4>Methods</h4>Newly diagnosed pulmonary TB patients with or without DM (TB n = 40; TB-DM n = 40) were recruited in Dhaka, Bangladesh. Clinical symptoms, sputum smear and culture conversion as well as chest radiography were ...[more]