Dataset Information

Association between newborn screening analyte profiles and infant mortality.

ABSTRACT:

Objective

To assess whether newborn screening analytes could be utilized beyond their traditional application to identify infants at high risk of mortality within the first 6 months of life.

Methods

We linked a province-wide newborn screening registry with health administrative databases to identify infant deaths within 6 months in a source population of live-born infants between 2010 and 2014. We used a nested case-control study design, in which all infant deaths between 7 days and 6 months of age were included as cases, and a random sample of infants from the source population were selected as controls and were matched to cases at a ratio of 10:1. We examined the association between mortality and screening analytes (acylcarnitines, amino acids, fetal-to-adult hemoglobin ratio, endocrine markers, and enzymes) using lasso regression to fit multivariable models.

Results

Among 350 infant deaths between 7 days and 6 months of age, and 3498 matched controls with complete data, our multivariable model demonstrated only modest ability to identify infant deaths (optimism-corrected c-statistic: 0.61, 95% confidence interval: 0.50-0.71).

Conclusion

We did not find newborn screening analytes to be strongly predictive of infant mortality between 7 days and 6 months of age in the general population of newborns. Future studies should investigate whether predictive modeling within more homogeneous cause-of-death categories could lead to improved predictive ability for infant mortality.

SUBMITTER: Fell DB

PROVIDER: S-EPMC7722351 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between newborn screening analyte profiles and infant mortality.

Fell Deshayne B DB Wilson Lindsay A LA Hawken Steven S Spruin Sarah S Murphy Malia M Potter Beth K BK Little Julian J Chakraborty Pranesh P Lacaze-Masmonteil Thierry T Wilson Kumanan K

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20190521 5

<b>Objective:</b> To assess whether newborn screening analytes could be utilized beyond their traditional application to identify infants at high risk of mortality within the first 6 months of life.<b>Methods:</b> We linked a province-wide newborn screening registry with health administrative databases to identify infant deaths within 6 months in a source population of live-born infants between 2010 and 2014. We used a nested case-control study design, in which all infant deaths between 7 days a ...[more]

PMID: 31046492

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Dataset Information

Association between newborn screening analyte profiles and infant mortality.

Objective

Methods

Results

Conclusion

Publications

Association between newborn screening analyte profiles and infant mortality.

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