Myonuclear content regulates cell size with similar scaling properties in mice and humans.
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ABSTRACT:
SUBMITTER: Hansson KA
PROVIDER: S-EPMC7722898 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Myonuclear content regulates cell size with similar scaling properties in mice and humans.
Hansson Kenth-Arne KA Eftestøl Einar E Bruusgaard Jo C JC Juvkam Inga I Cramer Alyssa W AW Malthe-Sørenssen Anders A Millay Douglas P DP Gundersen Kristian K
Nature communications 20201208 1
Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number (N) adheres to the relationship N = aV<sup>b</sup> where V is the cytoplasmic volume. N invariably scales sublinearly to V (b < 1), making larger cells even more DNA scarce. N scales linearly to cell surface in adult humans, in adul ...[more]
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