Ontology highlight
ABSTRACT:
SUBMITTER: Miller Jenkins LM
PROVIDER: S-EPMC7722985 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Miller Jenkins Lisa M LM Feng Hanqiao H Durell Stewart R SR Tagad Harichandra D HD Mazur Sharlyn J SJ Tropea Joseph E JE Bai Yawen Y Appella Ettore E
Biochemistry 20150316 11
The p53 tumor suppressor is a critical mediator of the cellular response to stress. The N-terminal transactivation domain of p53 makes protein interactions that promote its function as a transcription factor. Among those cofactors is the histone acetyltransferase p300, which both stabilizes p53 and promotes local chromatin unwinding. Here, we report the nuclear magnetic resonance solution structure of the Taz2 domain of p300 bound to the second transactivation subdomain of p53. In the complex, p ...[more]