Dataset Information

Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females.

ABSTRACT: Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) for CRF. Genotyping was performed using the Affymetrix Axiom and illumina 1?M arrays. After quality control and imputation, a linear regression-based association analysis was conducted using a total of 5,149,327 variants. Four loci associated with CRF were identified to reach genome-wide significance (P?-8), which located in 15q21.3 (rs17240160, P?=?1.73 × 10^-9, GCOM1), 3q25.31 (rs819865, P?=?8.56 × 10^-9, GMPS), 21q22.3 (rs117828698, P?=?9.59 × 10^-9, COL18A1), and 17q24.2 (rs79806428, P?=?3.85 × 10^-8, PRKCA). These loci (GCOM1, GMPS, COL18A1 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete young females. Our results suggest that these gene polymorphisms provide further genetic evidence for the polygenetic nature of cardiorespiratory endurance and be used as genetic biomarkers for future research.

SUBMITTER: Zhao Y

PROVIDER: S-EPMC7723046 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females.

Zhao Ying Y Huang Guoyuan G Chen Zuosong Z Fan Xiang X Huang Tao T Liu Jinsheng J Zhang Qing Q Shen Jingyi J Li Zhiqiang Z Shi Yongyong Y

Scientific reports 20200622 1

Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) f ...[more]

PMID: 32572135

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Project description:This study aimed to develop new equations to estimate cardiorespiratory fitness specifically for older adults and, secondly, to analyze the associations of cardiorespiratory fitness, both objectively measured and estimated using new equations, with cognitive performance. Ninety-two older adults (41 females, 65-75 years) from baseline data of a randomized controlled trial were analyzed ("ClinicalTrials.gov" Identifier: NCT03923712). Participants completed 4 measurement sessions including (i) physiological and health indicators in a laboratory setting, (ii) field-based fitness tests, (iii) sociodemographic and physical activity questionnaires, and (iv) a battery of neuropsychological tests to evaluate cognitive performance. The main findings were as follows: (i) a set of new equations with good predictive value for estimated cardiorespiratory fitness were developed (74-87%), using different scenarios of complexity and/or equipment requirements, and (ii) higher estimated cardiorespiratory fitness, even using its simplest equation (eCRF = - 1261.99 + 1.97 × 6 min walking test (m) + 1.12 × bioimpedance basal metabolic rate (kcal/day) + 5.25 × basal heart rate (bpm)), was associated with better cognitive performance evaluated by several neuropsychological tests (i.e., language, cognitive flexibility, fluency, attention, and working memory), similar to using objectively measured cardiorespiratory fitness. In summary, a new set of estimated cardiorespiratory fitness equations have been developed with predictive values ranging from 74 to 87% that could be used based on necessity, availability of equipment, resources, or measurement context. Moreover, similar to objectively measured cardiorespiratory fitness, this measure of estimated cardiorespiratory fitness was positively associated with performance on language, fluency, cognitive flexibility, attention, and working memory, independently of sex, age, and education level.

Dataset Information

Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females.

Publications

Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females.

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