Ontology highlight
ABSTRACT:
SUBMITTER: Komatsu KR
PROVIDER: S-EPMC7723054 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Komatsu Kaoru R KR Taya Toshiki T Matsumoto Sora S Miyashita Emi E Kashida Shunnichi S Saito Hirohide H
Nature communications 20201208 1
Biochemical assays and computational analyses have discovered RNA structures throughout various transcripts. However, the roles of these structures are mostly unknown. Here we develop folded RNA element profiling with structure library (FOREST), a multiplexed affinity assay system to identify functional interactions from transcriptome-wide RNA structure datasets. We generate an RNA structure library by extracting validated or predicted RNA motifs from gene-annotated RNA regions. The RNA structur ...[more]