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Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis.


ABSTRACT: In Asia, Vigna angularis (azuki bean) has been used as a traditional medicine to treat various diseases because of its biological properties. Osteoarthritis (OA) and osteoporosis (OP) are common regenerative bone diseases that are characterized by deterioration of joint and bone structure. In this study, we evaluated the effects of Vigna angularis extract (VAE) on monosodium iodoacetate (MIA)-induced OA and ovariectomy (OVX)-induced OP models. In the MIA-induced OA results, severe OA was alleviated by the administration of VAE. Extensive local damage in the cartilage and hemorrhagic and edematous of surrounding tissues were decreased by VAE treatment. Articular cartilage was almost intact except for a focal mild abrasion, and the surface was glistening, similar to that of the normal joint. In the OVX-induced OP results, bone mineral content (BMC) and bone mineral density (BMD) were recovered by VAE treatment, and it improved the microstructures of bone. These results show that VAE could inhibit OA and OP symptoms.

SUBMITTER: Lim HJ 

PROVIDER: S-EPMC7723184 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Beneficial effects of <i>Vigna angularis</i> extract in osteoporosis and osteoarthritis.

Lim Hyung Jin HJ   Park Sang-Ik SI   Bak Seon Gyeong SG   Cheong Sun Hee SH   Lee Soyoung S   Baek Young-Bin YB   Lee Chang-Min CM   Lee Kang Min KM   Lee Seung Woong SW   Lee Seung-Jae SJ   Rho Mun-Chual MC  

Food science & nutrition 20201020 12


In Asia, <i>Vigna angularis</i> (azuki bean) has been used as a traditional medicine to treat various diseases because of its biological properties. Osteoarthritis (OA) and osteoporosis (OP) are common regenerative bone diseases that are characterized by deterioration of joint and bone structure. In this study, we evaluated the effects of <i>Vigna angularis</i> extract (VAE) on monosodium iodoacetate (MIA)-induced OA and ovariectomy (OVX)-induced OP models. In the MIA-induced OA results, severe  ...[more]

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