Ontology highlight
ABSTRACT:
SUBMITTER: Ekanayaka P
PROVIDER: S-EPMC7723281 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ekanayaka Pathum P Lee Seo-Yong SY Herath Thilina U B TUB Kim Jae-Hoon JH Kim Tae-Hwan TH Lee Hyuncheol H Chathuranga Kiramage K Chathuranga W A Gayan WAG Park Jong-Hyeon JH Lee Jong-Soo JS
PLoS pathogens 20201124 11
VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the virus. In addition, FMDV VP1 modulates host IFN signal transduction. Here, we examined the ability of cell culture-adapted FMDV VP1(83K) and wild-type FMDV VP1(83E) to evade host immunity by blocking ...[more]