Ontology highlight
ABSTRACT:
SUBMITTER: de Assis Lima M
PROVIDER: S-EPMC7723338 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
de Assis Lima Maíra M da Silva Suély Vieira SV Serrano-Garrido Orlando O Hülsemann Maren M Santos-Neres Luana L Rodríguez-Manzaneque Juan Carlos JC Hodgson Louis L Freitas Vanessa M VM
Cellular signalling 20201106
ADAMTSs (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) are secreted proteases dependent on Zn<sup>2+</sup>/Ca<sup>2+</sup>, involved in physiological and pathological processes and are part of the extracellular matrix (ECM). Here, we investigated if ADAMTS-1 is required for invasion and migration of cells and the possible mechanism involved. In order to test ADAMTS-1's role in ovarian cancer cells (CHO, NIH-OVCAR-3 and ES2) and NIH-3 T3 fibroblasts, we modified the levels of AD ...[more]