Ontology highlight
ABSTRACT:
SUBMITTER: Atkins A
PROVIDER: S-EPMC7723410 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Atkins Alisa A Xu Michelle J MJ Li Maggie M Rogers Nathaniel P NP Pryzhkova Marina V MV Jordan Philip W PW
eLife 20201117
Mutations of SMC5/6 components cause developmental defects, including primary microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein <i>Smc5</i> is conditionally knocked out (cKO) in the developing neocortex. <i>Smc5</i> cKO mice exhibited neurodevelopmental defects due to neural progenitor cell (NPC) apoptosis, which led to reduction in cortical layer neurons. <i>Smc5</i> cKO NPCs formed DNA bridges during mitosis and underwent chromosome missegregation. SMC5/6 depleti ...[more]